Q) What are the recent projects that you are working on?

A) The one on DVD that is available for people to see now is Jeff, That Lives At Home, that my brother and I wrote and directed together. Then, there is the movie Your Sister's Sister, that stars Emily Blunt, Rosemarie DeWitt and myself. That's in theaters now and so is Safety Not Guaranteed, which stars myself, Aubrey Plaza and Jake Johnson.

Q) You mentioned starring in Your Sister's Sister and you are also inPeople Like Us. You are known more for your comedic abilities. What made you take on these more serious roles?

A) All the movies that I've done were comedies, comedic dramas or dramatic comedies. I think the comedy and the drama is all mixed up in these kinds of movies. It just boils down to if the script looks really good on a project then I'm down to do it, whether its funny or not. In the case of People Like Us, it's a smaller role, but I love the film. In the case of Your Sister's Sister, it was actually a movie idea that I had for a while that I pitched to a film maker. So, I was a part of putting that movie together in the first place.

Q) There is so much chemistry between you, Rosemarie and Emily in the film Your Sister's Sister. Did it come natural to you or did it take time to bond?

A) Chemistry is really odd and you never know what you're going to get. It worked out well with me, Emily and Rose. We didn't know each other that well beforehand. We talked a lot about our characters on the phone and then we just went in and let it rip.

Q) You're getting great reviews for your work in your films Your Sister's Sister and Safety Not Guaranteed. How does that make you feel?

A) It's good! It's better than being ignored and better than bad reviews. I'm really happy people are taking to these and hopefully it means we can continue to make the kinds of movies that we want to make.

Q) You are also in the movie Safety Not Guaranteed, which is about time travel. Do you think that will be a possibility in our lifetime?

A) I think what is important about this movie is that Kenneth, the character I'm playing, believes in time travel. That's what makes it such a great film. A person who believes time travel is possible is a special breed of human being. He's not sarcastic; he's a big childlike wide-eyed dreamer.

Q) Is your film Do-Deca-Pentathalon based on a true story?

A) It is based on two brothers my brother and I knew growing up in New Orleans who were born very close together in age. The only way they knew how to communicate was just by beating the living crap out of each other over sporting events. Our movie is about two brothers who create their own personal private 25 event Olympics in which only they compete. It's a funny and, ideally, moving portrait of two brothers who only know how to compete by beating the crap out of each other over the ping-pong table.

Q) What were some of your favorite events to film?

A) When you're filming sports, nothing can beat a sports montage. That allows you to go nuts and film all the best pieces. Every good sports film needs its montage and this film is certainly no exception. Filming that was a blast!

Q) The film is written and directed by you and your brother and you often collaborate together. Is that something you would recommend to others?

A) A lot of people have said to me, "I don't know how you guys work together without killing each other." To me, it's all about the chemistry. Jay and I are best friends. We are creatively in sync and we get along. I think it's really helpful to have a creative partner. You never know if you're going to kill somebody in a creative partnership. So, you have to find the right person.

Q) Who would win in a Do-Deca-Pentathalon between you and your brother?

A) That's a good question. I think it'd be pretty close. Ideally, it would be 13-12 and it would come down to the last event because that's always the most dramatic.

Q) What do you think it is about your movie that will interest viewers?

A) When you want to watch a movie you have a lot of options to choose from these days. For what I'd say about a movie like Do-Deca is that you'll never see a movie like this. It's got the style of a big broad Will Ferrell type sports comedy, but it's made for practically no money with non-famous actors in it. It's got the spirit of an independent film and I love that hybrid of sensibilities.

Q) What is it about independent films that makes you gravitate towards them?

A) The truth is, this is where I came up making films. Generally speaking, with an independent film you tend to have a little bit more input into the creative control. I actually like working on all films.

Q) You are a writer, producer, director and actor. Is there anything else you would like to try your hand at?

A) It sounds like I do all of these things, but at the end of the day I'm just making independent films. When you're making independent films, you have to do a lot of jobs - everybody does to a certain degree. I used to play in bands a lot when I was younger, but being a musician is kind of a crazy job being on tour. I prefer being a film maker because I can stay home more.

Q) You have great comedic timing, as evidenced on your show "The League." Is that something that came natural to you or have you had to hone it?

A) Comedic timing is tricky because sometimes editors can give you good comedic timing. To me, comedic timing has a lot to do with chemistry. It's playing off the energy from the person across from you and reacting to that correctly. It's a hard thing to analyze.

Q) Do you get to improvise much on "The League?"

A) All the dialogue is improvised. We shoot the show from an outline. Our show creators, Jeff and Jackie Schaffer, are really, really smart and very good at this. Jeff Schaffer worked on "Curb Your Enthusiasm" for years so he knows what he is doing. I think it's actually liberating to improvise, as opposed to working from a traditional script, because you get to kind of make it up as you go and if you're not feeling a certain thing then just say what you're feeling. There's something fun about that day after day.

Q) Did you expect your show "The League" to be such a fan favorite when it began?

A) You always hope the stuff you make will connect with people, but you never really know. We're really happy with the way people are taking to it.

Q) What advice would you offer up and coming actors?

A) Acting is a very tough profession. It's very hard on the spirits. I would highly recommend people who are actors to find friends who are film makers and create your own work. That way you're not at the mercy of the industry. Hopefully, you can put together a project you like and that way you don't have to wait around.

Q) Why is it important for you to be a part of the social networking site Twitter? Is it an important way for you to connect with fans and promote your work?

A) That's part of it, definitely. I also really like the idea that in this day in age there are lots of different ways to see movies. Movies don't have to be seen in the movie theater. Certain movies, honestly, are built to be seen at home. For instance, when a movie like Do-Deca-Pentathalon comes out (it's released on June 26th) before it hits the theater being able to talk about that on Twitter really brings attention to the film.

Q) Where can people go online to learn more about you?

A) You can follow me on Twitter at @MarkDuplass and I recommend Netflix movies. I tell you all about the movies that I'm in and I also tell good and bad jokes. You can catch it all there on Twitter.

Q) What would you like to say to everyone who is your fan and supporter?

A) Thank you so much for watching my stuff. There is a reason that I'm able to make what I'm able to make and it's because my fans show up. I really appreciate the support!